"I still think the most important molecule is dopamine," he said. Still, Flegr cautions that this discovery doesn't tell the whole story. And elevated GABA levels, Barragan says, "are associated with decreases in fear and anxiety." Now, here's the fascinating part: Disturbances in GABA are commonly seen in many psychiatric disorders, including schizophrenia. Toxo appeared to be inducing GABA production inside the dendritic cells, which excited GABA receptors on the outside of the very same dendritic cells, and sent them zooming through the body, and to the brain. Barragan was seeing something nobody had seen before. What's it doing in the immune system?" But there it was. "It didn't make any sense," Barragan said. What was agitating the dendritic cells?Īnd then they found it: a neurotransmitter called GABA. But how? The immune cells need to be stimulated in order to move-and the toxo itself obviously wasn't getting them going the cells didn't even seem to know they'd been infected. Toxo was using the immune system cells to travel through the body and get to the host's brain. "And we wondered, maybe the parasite is using these cells to get around." Using the cells as Trojan horses. As it turned out, he was right. "These are the gatekeepers of the immune system," he said. As Barragan and his team examined toxo in the blood of mice, they found the parasite living in a surprising place: inside the immune cells designed to kill them, a type of white blood cell called a "dendritic cell," after its treelike appearance. This research told a piece of the story but left many questions.Įnter Antonion Barragan, a researcher at the Center for Infectious Medicine at Karolinska Institute in Sweden. Elevated levels of dopamine are associated with schizophrenia. discovered that toxo has two genes for making l-DOPA, the precursor molecule to dopamine. How toxo might cause these changes remained a mystery. Other scientists have shown a connection between toxo and an increased risk of suicide. A toxo-infected person is more than twice as likely to be in a car accident-which Flegr attributes to the parasite's tendency to reduce reaction time-and has a higher than normal risk of developing schizophrenia.
Feline hookworms in humans pictures series#
Over the next 15 years, using experimentation and analysis of public health data, Flegr discovered a series of fascinating links between toxo and human behavior. He wondered: Could the toxo be responsible? And he'd also recently noticed a certain lack of fear in himself. "I would cross the street in traffic and not jump when the cars honked," he said. He knew the parasite reduced fear in rats so they'd be more likely to get eaten by cats.
The news that he carried the parasite gave him an idea. In 1990, Flegr happened to find out he had toxo himself-a colleague who studied the parasite had developed a new diagnostic test and decided to try it out on Flegr.
Pregnant women must be careful, though the Centers for Disease Control and Prevention warns that women infected during pregnancy face increased risk of miscarriage or birth defects. For most people, the parasite causes no obvious problems. ( Explore the human body.)Įven though toxo most often lives in cats, it infects millions of humans, jumping to us via contact with litter boxes, contaminated water, or undercooked meat. And not only does the parasite ride those cells like a city bus, but it also turns them into tiny chemical factories, producing a neurotransmitter known to reduce fear and anxiety in rats-and in humans. In order to travel throughout the body and, most importantly, to the brain, toxo hijacks the very cells designed to destroy foreign invaders: the white blood cells.
Two months ago, a team of Swedish scientists uncovered a key piece of the puzzle. ( Watch: Secret lives of house cats revealed.) But until very recently, scientists knew little about how toxo might be doing this. "Toxo," which typically infects cats, is famous among scientists for its clever tactic of jumping from one cat to another by infecting rats and altering their behavior to make them more likely to be eaten by another cat, thus transferring the parasite to a new host.įlegr discovered that the behaviors that toxo provokes in rats in order to get them eaten-slowed reaction times, lethargy, reduction in fear-also show up in infected humans. Over the past year, a Czech evolutionary biologist named Jaroslav Flegr has made headlines for a radical claim: that a common parasite called Toxoplasma gondii is controlling our brains.
0 kommentar(er)
